|Quantitative Cerebral Blood Flow measurements
Similarly, absolute quantification of cerebrovascular haemo-dynamics is possible by QSPECT imaging.
Using 123I-iodoamphetamine SPECT and the DTARG method, CBF at rest and following acetazolamide challenge can be determined in a single session3). Test-retest variability within systems is minimal, and agreement with technically more demanding 18O-water PET high4).
3) Kim K, et al.: Quantitative mapping of basal and vasoreactive cerebral blood flow using split-dose 123I-iodoamphetamine and single photon emission computed tomography. NeuroImage 2006; 33 :1126–1135
4) Iida H , et al.: Multicenter Evaluation of a Standardized Protocol for Rest and Acetazolamide Cerebral Blood Flow Assessment Using a Quantitative SPECT Reconstruction Program and Split-Dose
123I-Iodoamphetamine. J Nucl Med 2010; 51: 1624–1631